Volume 20, Issue 141 (2023)                   FSCT 2023, 20(141): 36-47 | Back to browse issues page

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souri P, emamifar A, Davati N. Time–kill kinetic of nano ZnO-loaded nanoliposomes against Escherichia coli and Staphylococcus aureus. FSCT 2023; 20 (141) :36-47
URL: http://fsct.modares.ac.ir/article-7-70287-en.html
1- Bu-Ali Sina University
2- Bu-Ali Sina University , a.emamifar@basu.ac.ir
Abstract:   (644 Views)
The objective of this study was to in-vitro investigation of antimicrobial activity effect of nano-ZnO loaded nanoliposomes at different level of lecithin: nano-ZnO ratio (5:1, 15:1, and 25:1 w/w) against Escherichia coli (ATCC 2592) and Staphylococcus aureus (ATCC 25923). Nano-ZnO loaded nanoliposomes were prepared through thin layer hydration sonication and heat methods. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of nano-ZnO loaded nanoliposomes and free nano-ZnO against Escherichia coli and Staphylococcus aureus were determined and their antimicrobial activities were evaluated by time- kill curve analysis. Results showed that the encapsulation of nano-ZnO in nanoliposome systems significantly increased antimicrobial activities of them by increasing their penetration into the microbial cell. Nano-ZnO loaded nanoliposomes were prepared through thin layer hydration showed higher antimicrobial activity compared to those prepared by heat method. From the time- kill curves, the log phase growth of Escherichia coli (8 hours) and Staphylococcus aureus (7 hours) in the medium containing nano-ZnO loaded nanoliposomes prepared through the thin layer hydration sonication at the highest level of lecithin: nano-ZnO ratio (25:1 w/w) at MIC and MBC values decreased to 5 and 4 hours and to 2 and less than 1 hours, respectively.
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Article Type: Original Research | Subject: Nanotechnology in the food industry (nanoparticles, nanocapsulations, nanomolies, etc.)
Received: 2023/07/4 | Accepted: 2023/08/12 | Published: 2023/10/23

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