Volume 16, Issue 91 (2019)                   FSCT 2019, 16(91): 291-303 | Back to browse issues page

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Estakhr P, tavakoli J, beigmohammadi F, Alaee S. Optimization of antioxidant activity of Ferula persica by Ultrasound waves using various ratios of ethanol-water solvent at different temperatures whit Response Surface Methodology. FSCT 2019; 16 (91) :291-303
URL: http://fsct.modares.ac.ir/article-7-33164-en.html
Optimization of antioxidant activity of Ferula persica by Ultrasound waves using various ratios of ethanol-water solvent at different temperatures whit Response Surface Methodology
Parviz Estakhr1 , Javad Tavakoli 2, Faranak Beigmohammadi3 , Shima Alaee3
1- Kermanshah branch, Islamic Azad University
2- jahrom university , ja_tavakoli@yahoo.com
3- Islamic Azad University
Abstract:   (4746 Views)
In the present study, the optimization process of phenolic compounds extraction and antioxidant activity (DPPH radical-scavenging assay, FRAP test, and oxidative stability index) of Ferula persica was evaluated using ultrasound waves through response surface methodology (RSM). To optimize the extraction process from the central composite design with three independent variables including time (5, 27.5 and 50 minutes), temperature (25, 45 and 65 ° C) and ethanol ratio in water-ethanol solvent (0, 50 and 100% ) was used. In general, the results of analysis of variance showed that independent parameters had a significant effect on the DPPH radical-scavenging assay, FRAP test, and oxidative stability index of Ferula persica extract, their Correlation coefficients (R2) were 0.91, 0.94 and 0.93, respectively. However, the proposed model for total phenolic compounds does not indicate the significant effect of these mention parameters. The results showed that the optimum conditions for antioxidant activity of Ferula persica extract were at 52.9 ° C and 53.5% ethanol concentration in water-ethanol solvent with 34.1 minutes for sonication. It was also found that the experimental results were close to those predicted by the response surface methodology. Evaluation of the antioxidant activity results of various extracts of Ferula persica showed that in most conditions, it has a suitable antioxidant power.
Keywords: Ferula persica, Ultrasound waves, Antioxidant Activity, Optimization, Response surface methodology.
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Article Type: Original Research | Subject: Enriching food
Received: 2019/05/21 | Accepted: 2019/10/12 | Published: 2019/09/1
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