Volume 21, Issue 157 (2025)
FSCT 2025, 21(157): 100-122 |
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Saadatzadeh A, Honarmand R, Gholipour S. In vitro Comparison of anti-bacterial effect of probiotic extract from Lactobacillus casei with current antibiotics against four pathogenic bacteria strains. FSCT 2025; 21 (157) :100-122
URL: http://fsct.modares.ac.ir/article-7-74572-en.html
URL: http://fsct.modares.ac.ir/article-7-74572-en.html
1- Department of Food and Drug Control, Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran , afsaadat@gmail.com
2- Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Department of Food and Drug Control, Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Department of Food and Drug Control, Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract: (111 Views)
The purpose of this study was to investigate the activity of probiotic extract achieved from Lactobacillus casei against the growth of 4 standard drug-resistant bacterial strains and to compare its antimicrobial effect with some common antibiotics in vitro. L. casei was cultured in standard MRS medium and under anaerobic conditions. Probiotic dry extract was extracted after separating the mass of living cells by centrifugation and stabilized by lyophilization. The investigation of antimicrobial activity was done using the diffusion-disc method, the results were analyzed using SPSS software with a significance level of P<0.05. There was a significant difference between all antimicrobial agents (P<0.05). The findings showed that LPE was able to control resistant pathogenic bacteria. The highest inhibitory effect of LPE was evaluated against Staphylococcus aureus with a diameter of 26 mm of non-growth halo and on the other hand, the lowest effect was evaluated against Escherichia coli with a diameter of 13.3 mm of non-growth halo. Although LPE had the greatest effect compared to antibiotic agents against 3 bacterial strains, it was weaker than gentamicin and streptomycin in the case of Salmonella typhi. Despite the significant antibacterial effects of LPE against several strains of gram-negative and gram-positive bacteria, more studies are necessary before its clinical administration and to prove its beneficial role in the treatment of infectious diseases.
Article Type: Original Research |
Subject:
Food Microbiology
Received: 2024/04/5 | Accepted: 2024/06/1 | Published: 2025/02/19
Received: 2024/04/5 | Accepted: 2024/06/1 | Published: 2025/02/19
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