Volume 9, Issue 34 (2012)                   FSCT 2012, 9(34): 129-136 | Back to browse issues page

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Separation and Identification of Imidazole-based Antifungal Residues in pasteurized Milk of Iran. FSCT 2012; 9 (34) :129-136
URL: http://fsct.modares.ac.ir/article-7-3445-en.html
Abstract:   (7083 Views)
Antifungal drugs have an important role for treatment of fungal skin diseases of livestock and prophylaxis. These compounds belong to the different chemical groups but Imidazole group is one of the most important groups. In this study 60 pasteurized milk samples were analyzed by liquid-liquid microextraction and high performance liquid chromatography. And the efficiency of solid phase extraction and high performance chromatography-UV spectroscopy was evaluated in the extraction and determination of Ketoconazole and Clotrimazole analytes in milk.  In this research, after full validation, detection and quantitation limits were 0.01 μg.ml-1 and 0.1 μg.mL-1 for Ketoconazole and Clotrimazole. The linear range of calibration was relatively wide (0.01-100 μg.ml-1). The relative standard deviation was 0.1-7.5% for Ketoconazole and 0.1-8.5% for Clotrimazole. Monitoring of 60 pasteurized milk in different seasons for Clotrimazole and Ketoconazole residue with 0.01 ppm detection limit, demonstrated there is no detectable amounts of these antifungal residues in pasteurized milk.
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Received: 2009/07/2 | Accepted: 2010/10/3 | Published: 2012/07/1

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